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Home - Products - GPCR/G Protein - Adrenergic Receptor - CL 316243 disodium

CL 316243 disodium

CAS No. 138908-40-4

CL 316243 disodium( CL316243 disodium )

Catalog No. M11615 CAS No. 138908-40-4

CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CL 316243 disodium
  • Note
    Research use only, not for human use.
  • Brief Description
    CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM.
  • Description
    CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM; Displays >10000-fold selective over β1 and β2 receptors; Significantly increases brown adipose tissue thermogenesis and resting metabolic rate in mice, also increases the concentration of insulin receptors and decreases the levels of serum insulin and blood glucose during the glucose overloading test.Obesity Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks Dosage:0.1 mg/kg/day Administration:once a day; 1 weeks Result:Exhibited a premium effect of obesity in mice.
  • Synonyms
    CL316243 disodium
  • Pathway
    GPCR/G Protein
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    138908-40-4
  • Formula Weight
    465.8
  • Molecular Formula
    C20H18ClNNa2O7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 20 mg/mL (42.94 mM助)
  • SMILES
    CC(CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NCC(C3=CC(=CC=C3)Cl)O.[Na+].[Na+]
  • Chemical Name
    5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Berlan M, et al. J Pharmacol Exp Ther. 1994 Mar;268(3):1444-51. 2. Himms-Hagen J, et al. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82. 3. Yoshida T, et al. Life Sci. 1994;54(7):491-8.
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